This study investigates the pattern of knowledge spillovers arising from patent activity between European regions. A Bayesian hierarchical model is developed that specifies region-specific latent effects parameters modeled using a connectivity structure between regions that can reflect geographical proximity in conjunction with technological and other types of proximity. This approach exploits the fact that interregional relationships may exhibit industry-specific technological linkages or transportation network linkages, which is in contrast with traditional studies relying exclusively on geographical proximity. We also allow for both symmetric and asymmetric knowledge spillovers between regions, and for heterogeneity across the regional s...